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KMID : 1039420170510030314
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Journal of Pathology and Translational Medicine
2017 Volume.51 No. 3 p.314 ~ p.319
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Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test
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Jeong Hoi-Seon
Hong Sung-Ran
Chae Seoung-Wan
Jin So-Young
Yoon Hye-Kyoung
Lee Ju-Hie
Kim Eun-Kyung
Ha Sook-Tai
Kim Sung-Nam
Park Eun-Jung
Jung Jong-Jae
Sung Sun-Hee
Lim Seung-Cheoul
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Abstract
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Background: Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories.
Methods: Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors.
Results: A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p = .018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p = .006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity.
Conclusions: Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS.
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KEYWORD
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Papanicolaou test, Cervical cytology, Unsatisfactory, Liquid-based cytology, Conventional smear
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